Scientist I Imaging and Pharmacology

**_What can we offer you?_** _Apart from job satisfaction, we can offer you:_ **_HEALTH_** * _Medical, Dental and Vision benefits for you and your family, including Flexible Spending Accounts (FSA)_ **_YOURSELF_** * _Paid time off policy including holidays and sick time_ * _Internal growth and development programs & trainings_ **_WEALTH_** * _401(k) program, life & accident insurance and disability insurance_ We are seeking a motivated and skilled Scientist I to support our invivo imaging studies using small animal models. This role is central to our preclinical research team and involves hands-on work with nuclear medicine (PET/SPECT), computed tomography (CT), and magnetic resonance imaging (MRI). The successful candidate will play a key role in project leadership, with the opportunity to oversee staff and lab spaces. They will also provide technical support across a range of in vivo disease models, perform dosing and surgical procedures, and contribute to team leadership by mentoring junior staff. This position offers an exciting opportunity to evolve into a strategic leadership role within a fast-paced, collaborative research environment. Whether leading a small team or contributing as a senior individual contributor, you'll have the autonomy to drive research excellence and help shape the future of preclinical imaging studies. **Key Responsibilities** **Team Leadership & Staff Development** * Lead or support day-to-day activities within the invivo team, ensuring alignment with project timelines and goals. * May oversee and develop junior staff (2-4 members) provide training and technical guidance as needed. * Contribute to the management and optimization of laboratory space, including equipment and supply maintenance. * Develop, write and enforce laboratory-specific standard operating procedures (SOP’s) * Evaluate study protocols and collaborate with Discovery Research teams during protocol development. * Liaise with IACUC and internal stakeholders to ensure compliance with animal use protocols (AUP’s) * Lead onboarding and integration of new team members. **Study Support & Execution** * Participate in protocol development and review with Discovery Research and cross-functional teams. * Assist in coordinating study scheduling and establish timelines for protocol execution. * Execute a wide range of study types including: * Efficacy, biodistribution, pharmacokinetics, toxicokinetic, and xenograft models. * Perform dosing and surgical procedures such as: * IV, IP, SC, IM, PO administrations * Perfusion, tissue resection, microdissection * Biological sampling (blood, CSF, organs) * Survival surgery and CNS administration (preferred but not required) * Assist in image acquisition (PET, SPECT, CT, MRI) and related procedures. * Handle radioactive and BSL2 materials, including sample processing, gamma counting, and proper waste disposal. * Ensure strict adherence to laboratory SOPs and regulatory guidelines (IACUC, radiation safety, lab safety). * Ensure accurate data collection, analysis and reporting. * Maintain complete and clear laboratory records. * Monitor and report on animal health in collaboration with attending veterinarian. * Represent in vivo operations in meetings and cross-functional communications. **Functional Competencies (Technical knowledge/Skills)** * ​Some understanding of biology, pharmacology, or small animal imaging in the context of pharmaceutical research * ​Ability to multi-task * ​Comfort with various computer operating systems and programs  * ​Strong written and oral communication skills   * Occasional weekend and after-hours work as needed  * ​Ability to lift 50 pounds  **​Highly Desired Competencies**   * ​Strong proficiency in IV dosing and minor surgical procedures * Microdissection of specific tissues (e.g., lymph nodes, brain sections) * Hands-on experience in a preclinical imaging environment **Experience, Education, and Certifications** * ​Bachelor’s degree in Biology, Animal Science, or related field, with 7+ years of relevant in vivo research experience or higher degree with 5+ years of relevant in vivo research experience. * Demonstrated experience mentoring laboratory staff. * Competence with computer systems and laboratory data platforms. * Ability to lift up to 50 pounds. * Availability to work occasional weekends as required.  This role is based in the Perceptive office/lab located in Needham, MA.  The annual base salary range for this role is $65,305-$121,287.  This range represents the anticipated initial annual salary and may vary depending on several factors including the candidate’s experience and skills and may be subject to market rate adjustment.